Category Archives: Ongoing Projects

High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

A new patent assigned to our laboratory on December 18, 2018. U S Patent number: 10155221 Abstract: The invention is a high-throughput voltage screening crystallographic device and methodology that uses multiple micro wells and electric circuits capable of assaying different crystallization condition for the same or different proteins of interest at the same of different…

Neuroscience of Nicotine: Mechanisms and Treatment

Manuel Delgado Vélez Ph.D and José Lasalde Dominicci Ph.D has been recognized experts on the subject and share their contribution as co-authors of HIV – Infected Subjects and Tobacco Smoking: A Focus on Nicotine Effects on the Brain Neuroscience of Nicotine: Mechanisms and Treatment covers all necessary and fundamental information of the neurobiological system addressing…

Preparation of nAChR cristals for high-resolution studies using the detergent analog LFC-16 and monoclonal antibodies

nA The nicotinic acetylcholine receptor (nAChR) is a prime example of a multimeric membrane complex that although is one of the most widely studied ion channels, its high-resolution structure has remained elusive. These receptors are important as the biological target for the therapeutic development is in a great number of diseases such as the Alzheimer’s Disease, Myasthenic Syndrome,…