Preparation of nAChR cristals for high-resolution studies using the detergent analog LFC-16 and monoclonal antibodies
nA The nicotinic acetylcholine receptor (nAChR) is a prime example of a multimeric membrane complex that although is one of the most widely studied ion channels, its high-resolution structure has remained elusive. These receptors are important as the biological target for the therapeutic development is in a great number of diseases such as the Alzheimer’s Disease, Myasthenic Syndrome,…