We are investigating the effect of open-channel blockers such as fluoxetine, memantine and quinidine sulfate on neuromuscular transmission in mice bearing the αC418W and εL269F mutation in the nicotinic acetylcholine receptor (nAChR) using Two electrode voltage clamp technique by exposing the muscle fibers to physiological concentrations of the drugs mentioned above. Recent studies suggested that fluoxetine reduces the open time of the nAChR channels for the εL269F mutant without changing other physiological parameters. In order to investigate if there is an improve in the motor performance a chronic administration of a particular drug is also another approach done in the laboratory to see whether a drug treatment would improve the decremental response that Slow-Channel Syndrome (SCS) mutations exhibit to repetitive nerve stimulation (rsEMG).