October 11, 2016
Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

Carlos A. Báez-Pagán1 & Manuel Delgado-Vélez1 & José A. Lasalde-Dominicci1,2 20 November 2013 /Accepted: 12 March 2015 /Published online: 14 April 2015 # Springer Science+Business Media New York 2015

September 21, 2016
Inflamación periferal inducida por VIH: un problema sin resolver.

Delgado-Vélez, M and Lasalde-Dominicci, JA. Revista Puertorriqueña de Medicina y Salud Pública. (2016). Mar. Vol 54, 92-96.

September 20, 2016
Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies.

Quesada O, González-Freire C, Ferrer MC, Colón-Sáez JO, Fernández-García E, Mercado J, Dávila A, Morales R, Lasalde-Dominicci JA.Sci Rep. 2016 Sep 19;6:32766. doi: 10.1038/srep32766.PMID:27641515

April 3, 2016
Heterogeneous Inhibition in Macroscopic Current Responses of Four Nicotinic Acetylcholine Receptor Subtypes by Cholesterol Enrichment

Báez-Pagán, C.A., Del Hoyo-Rivera, N., Quesada, O., Lasalde-Dominicci, J.A. (2016) Heterogeneous inhibition in macroscopic current responses of four nicotinic acetylcholine receptor subtypes by cholesterol enrichment. J Membr Biol. 2016 Aug;249(4):539-49. doi: 10.1007/s00232-016-9896-z. Epub 2016 Apr 26.  PMID: 27116687

December 11, 2015
The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response.

Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. Clin Transl Immunology. 2015 Dec 11;4(12):e53. doi: 10.1038/cti.2015.31. eCollection 2015 Dec. PMID:26719799

November 13, 2015
Decreased glial and synaptic glutamate uptake in the striatum of HIV-1 gp120 transgenic mice.

Melendez RI, Roman C, Capo-Velez CM, Lasalde-Dominicci JA. J Neurovirol. 2015 Nov 13. PMID:26567011

November 13, 2015
Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder.

Ramos FM, Delgado-Vélez M, Ortiz ÁL, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA. J Neurovirol. 2015 Nov 13. PMID:26567012

October 8, 2015
Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.
Padilla-Morales LF, Colón-Sáez JO, González-Nieves JE, Quesada-González O, Lasalde-Dominicci JA. Biochim Biophys Acta. 2016 Jan;1858(1):47-56. doi: 10.1016/j.bbamem.2015.10.002. Epub 2015 Oct 8. PMID:26454038
October 2, 2015
Functionality and stability data of detergent purified nAChR fromTorpedousing lipidic matrixes and macroscopic electrophysiology.

Luis F. Padilla-Morales, José O. Colón-Sáez, Joel E. González-Nieves, Orestes Quesada-González, José A. Lasalde-Dominicci Data in Brief 6 (2016) 433-437 doi:10.1016/j.bbamem.2015.10.02

September 9, 2015
Lateral Diffusion, Function, and Expression of the Slow Channel Congenital Myasthenia Syndrome αC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components.

Oyola-Cintrón J, Caballero-Rivera D, Ballester L, Baéz-Pagán CA, Martínez HL, Vélez-Arroyo KP, Quesada O, Lasalde-Dominicci JA. J Biol Chem. 2015 Oct 30;290(44):26790-800. doi: 10.1074/jbc.M115.678573. Epub 2015 Sep 9.PMID:26354438

April 22, 2015
Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.

Biaggi-Labiosa NM, Avilés-Pagán E, Caballero-Rivera D, Báez-Pagán CA, Lasalde-Dominicci JA. Neuropharmacology. 2015 Dec;99:273-84. doi: 10.1016/j.neuropharm.2015.04.22. Epub 2015 May 6. PMID:25957813

April 14, 2015
Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation.

Báez-Pagán CA, Delgado-Vélez M, Lasalde-Dominicci JA. J Neuroimmune Pharmacol. 2015 Sep;10(3):468-76. doi: 10.1007/s11481-015-9601-5. Epub 2015 Apr 14. PMID:25870122

October 23, 2014
Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome

Zhu H, Grajales-Reyes GE, Alicea-Vázquez V, Grajales-Reyes JG, Robinson K, Pytel P, Báez-Pagán CA, Lasalde-Dominicci JA, Gomez CM. Exp Neurol. 2015 Aug;270:88-94. doi:10.1016/j.expneurol.2014.10.008. Epub 2014 Oct 23. PMID:25448156

March 6, 2012
Tryptophan scanning mutagenesis reveals distortions in the helical structure of the ?M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.

Caballero-Rivera, D., Cruz-Nieves, O.A., Oyola-Cintrón, J., Torres-Nunez, D.A., Otero-Cruz, J.D., Lasalde-Dominicci, J.A. (2012) Channels (Austin) Mar 1;6(2). (Epub ahead of print)

February 26, 2012
Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions. The Pharmacogenomics Journal (Epub ahead of print)

GE Grajales-Reyes, CA Baez-Pagan, H Zhu, JG Grajales-Reyes, M Delgado-Velez, WF Garcıa-Beltran, CA Luciano,
O Quesada, R Ramırez, CM Gomez and JA Lasalde-Dominicci (2012)

February 1, 2012
Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions. The Pharmacogenomics Journal (Epub ahead of print)

GE Grajales-Reyes, CA Baez-Pagan, H Zhu, JG Grajales-Reyes, M Delgado-Velez, WF Garcıa-Beltran, CA Luciano,
O Quesada, R Ramırez, CM Gomez and JA Lasalde-Dominicci (2012)

August 5, 2011
Fourier transform coupled tryptophan scanning mutagenesis identifies a bending point on the lipid-exposed δM3 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.

Caballero-Rivera D., Cruz-Nieves O.A., Oyola-Cintrón J., Torres-Núñez D.A., Otero-Cruz J.D., and Lasalde-Dominicci J.A. (2011) Channels (Austin). Jul-Aug;5(4):345-56. PMID: 21785268

February 26, 2011
Effects of lipid-analog detergent solubilization on the functionality and lipidic cubic phase mobility of the Torpedo californica nicotinic acetylcholine receptor.

Padilla-Morales L.F., Morales-Pérez C.L., De La Cruz-Rivera P.C., Asmar-Rovira G., Báez-Pagán C.A., Quesada O., and Lasalde-Dominicci J.A. (2011)

January 26, 2011
Shared Subcellular Distribution Patterns with Caveolin-1 Cell Mol. Neurobiol.

Salgado I.K., Serrano M., Garcia J.O., Martinez N.A., Maldonado H.M., Báez-Pagán C.A., Lasalde-Dominicci J.A., and Silva W.I. (2011) SorLA in Glia  (Epub ahead of print) PMID: 22127416 .

January 1, 2011
Up-regulation of the neuronal nicotinic receptor α7

Ballester L.Y., Capo-Velez C.M., Garcia-Beltran W.F., Ramos F.M., Vazquez-Rosa E., Rios R., Mercado J.R., Melendez R.I. and Lasalde-Dominicci J.A. (2011)

January 17, 2010
Decoding pathogenesis of slow-channel congenital myasthenic syndromes using recombinant expression and mice models.

Otero-Cruz J.D., Baez-Pagan C.A., Dorna-Perez L., Grajales-Reyes G.E., Ramirez-Ordoñez R.T., Luciano C.A., Gomez C.M., and Lasalde-Dominicci J.A. (2010)  P R Health Sci J. (1):4-17. Review. PMID: 20222328.

November 26, 2009
Triiodothyronine (T3) action on aquatic locomotor behavior during metamorphosis of the bullfrog Rana catesbeiana, Int J Dev Biol.

Fernandez-Mongil, M., Venza, C. J., Rivera, A., Lasalde-Dominicci, J. A., Burggren, W., and Rojas, L. V., (2009) 53(1):101-8. PMID: 19123131.

July 8, 2009
Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors. Cell Mol Neurobiol.

Lopez-Hernandez G.Y., Biaggi-Labiosa N.M., Torres-Cintron A., Ortiz-Acevedo A., and Lasalde-Dominicci J.A. (2009)

July 26, 2008
Aromaticity at the water-hydrocarbon core interface of the membrane: Consequences on the nicotinic acetylcholine receptor

Lizardi-Ortiz, J. E., Hyzinski-Garcia, M. C., Fernandez-Gerena, J. L., Osorio-Martinez, K. M., Velazquez-Rivera, E., Valle-Aviles, F. L., and Lasalde-Dominicci, J. A. (2008)  Channels (Austin) 2, 191-201. PMID: 18836298.

July 18, 2008
Contribution of Position alpha4S336 on Functional Expression and Up-regulation of alpha4beta2 Neuronal Nicotinic Receptors

Lopez-Hernandez, G. Y., Biaggi-Labiosa, N. M., Torres-Cintron, A., Ortiz-Acevedo, A., and Lasalde-Dominicci, J. A. (2008) Cell Mol Neurobiol. PMID: 18818999.

May 5, 2008
Fourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains, Biochim Biophys AcFourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains, Biochim Biophys AcFourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains

Otero-Cruz, J. D., Torres-Nunez, D. A., Baez-Pagan, C. A., and Lasalde-Dominicci, J. A. (2008)  Biochim Biophys Acta 1784, 1200-1207. PMID: 18346473

May 3, 2008
Potential role of caveolin-1-positive domains in the regulation of the acetylcholine receptor’s activatable pool: Implications in the pathogenesis of a novel congenital myasthenic syndrome

Baez-Pagan, C. A., Martinez-Ortiz, Y., Otero-Cruz, J. D., Salgado-Villanueva, I. K., Velazquez, G., Ortiz-Acevedo, A., Quesada, O., Silva, W. I., and Lasalde-Dominicci, J. A. Channels (Austin) 2, 180-190. PMID: 18836288.

April 9, 2008
Tryptophan scanning of the acetylcholine receptor’s betaM4 transmembrane domain: Decoding allosteric linkage at the lipid-protein interface with ion-channel gating

Diaz-De Leon, R., Otero-Cruz, J. D., Torres-Nunez, D. A., Casiano, A., and Lasalde-Dominicci, J. A. (2008) Channels (Austin) 2. PMID: 19066450.

April 7, 2008
Functional contribution of alpha3L8′ to the neuronal nicotinic alpha3 receptor

Nieves-Cintron, M., Caballero-Rivera, D., Silva, W. I., Navedo, M. F., and Lasalde-Dominicci, J. A. (2008) J Neurosci Res 86, 2884-2894. PMID: 18615639.

March 25, 2007
Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking, Cell Mol Neurobiol 27

Ochoa, E. L., and Lasalde-Dominicci, J. 609-639. PMID: 17554626.

March 20, 2007
Tryptophan-scanning mutagenesis in the alphaM3 transmembrane domain of the muscle-type acetylcholine receptor. A spring model revealed, J Biol Chem 282

Otero-Cruz, J. D., Baez-Pagan, C. A., Caraballo-Gonzalez, I. M., and Lasalde-Dominicci, J. A.  9162-9171. PMID: 17242410.

March 7, 2007
Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women

Wojna, V., Robles, L., Skolasky, R. L., Mayo, R., Selnes, O., de la Torre, T., Maldonado, E., Nath, A., Melendez, L. M., and Lasalde-Dominicci, J. J Neurovirol 13, 561-568. PMID: 18097887.

July 2, 2006
The polarity of lipid-exposed residues contributes to the functional differences between Torpedo and muscle-type nicotinic receptors, J Membr Biol 214, 131-138.

Guzman, G. R., Ortiz-Acevedo, A., Ricardo, A., Rojas, L. V., and Lasalde-Dominicci, J. A. PMID: 17530159.

May 20, 2006
Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation, Mol Cell Neurosci 32

Navedo, M. F., Lasalde-Dominicci, J. A., Baez-Pagan, C. A., Diaz-Perez, L., Rojas, L. V., Maselli, R. A., Staub, J., Schott, K., Zayas, R., and Gomez, C. M. 82-90. PMID: 16624571.

May 16, 2006
Contribution of valine 7′ of TMD2 to gating of neuronal alpha3 receptor subtypes, J Neurosci Res 84

Nieves-Cintron, M., Caballero-Rivera, D., Navedo, M. F., and Lasalde-Dominicci, J. A.

April 3, 2006
Macroscopic properties of spontaneous mutations in slow-channel syndrome: correlation by domain and disease severity, Synapse 60

Zayas, R., Lasalde-Dominicci, J., and Gomez, C. M. (2006) 441-449. PMID: 16881075.

August 11, 2004
Tryptophan scanning mutagenesis in the TM3 domain of the Torpedo californica acetylcholine receptor beta subunit reveals an alpha-helical structure, Biochemistry 43, 10064-10070.

Santiago, J., Guzman, G. R., Torruellas, K., Rojas, L. V., and Lasalde-Dominicci, J. A. PMID: 15287734.

March 18, 2004
Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha-TM3 domain in channel gating: differences between Torpedo and muscle-type AChR, Biochemistry 43, 78-84.

Navedo, M., Nieves, M., Rojas, L., and Lasalde-Dominicci, J. A. PMID: 14705933

February 26, 2004
ryptophan scanning mutagenesis of the gammaM4 transmembrane domain of the acetylcholine receptor from Torpedo californica, J Biol Chem 279, 42250-42257.

Ortiz-Acevedo, A., Melendez, M., Asseo, A. M., Biaggi, N., Rojas, L. V., and Lasalde-Dominicci, J. A. PMID: 15247226.

September 7, 2003
Tryptophan scanning mutagenesis in the alphaM3 transmembrane domain of the Torpedo californica acetylcholine receptor: functional and structural implications, Biochemistry 42, 12243-12250.

Guzman, G. R., Santiago, J., Ricardo, A., Marti-Arbona, R., Rojas, L. V., and Lasalde-Dominicci, J. A.