Publications:

 

Fernández-Mongil, M., Venza, C. J., Rivera, A., Lasalde-Dominicci, J. A., Burggren, W., and Rojas, L. V., (2008) Triiodothyronine (T3) action on aquatic locomotor behavior during metamorphosis of the bullfrog Rana catesbeiana, Int. J. Dev. Biol. 52. In press (2008) doi:10.1387/ijdb.072307mf.
Otero-Cruz, J. D., Torres-Nunez, D. A., Baez-Pagan, C. A., and Lasalde-Dominicci, J. A. (2008) Fourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains, Biochim Biophys Acta 1784, 1200-1207. PMID: 18346473.
Nieves-Cintron, M., Caballero-Rivera, D., Silva, W. I., Navedo, M. F., and Lasalde-Dominicci, J. A. (2008) Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor, J Neurosci Res 86, 2884-2894. PMID: 18615639.
Lopez-Hernandez, G. Y., Biaggi-Labiosa, N. M., Torres-Cintron, A., Ortiz-Acevedo, A., and Lasalde-Dominicci, J. A. (2008) Contribution of Position alpha4S336 on Functional Expression and Up-regulation of alpha4beta2 Neuronal Nicotinic Receptors, Cell Mol Neurobiol. PMID: 18818999.
Lizardi-Ortiz, J. E., Hyzinski-Garcia, M. C., Fernandez-Gerena, J. L., Osorio-Martinez, K. M., Velazquez-Rivera, E., Valle-Aviles, F. L., and Lasalde-Dominicci, J. A. (2008) Aromaticity at the water-hydrocarbon core interface of the membrane: Consequences on the nicotinic acetylcholine receptor, Channels (Austin) 2, 191-201. PMID: 18836298.
Diaz-De Leon, R., Otero-Cruz, J. D., Torres-Nunez, D. A., Casiano, A., and Lasalde-Dominicci, J. A. (2008) Tryptophan scanning of the acetylcholine receptor's betaM4 transmembrane domain: Decoding allosteric linkage at the lipid-protein interface with ion-channel gating, Channels (Austin) 2. PMID: 19066450.
Baez-Pagan, C. A., Martinez-Ortiz, Y., Otero-Cruz, J. D., Salgado-Villanueva, I. K., Velazquez, G., Ortiz-Acevedo, A., Quesada, O., Silva, W. I., and Lasalde-Dominicci, J. A. (2008) Potential role of caveolin-1-positive domains in the regulation of the acetylcholine receptor's activatable pool: Implications in the pathogenesis of a novel congenital myasthenic syndrome, Channels (Austin) 2, 180-190. PMID: 18836288.
Asmar-Rovira, G. A., Asseo-Garcia, A. M., Quesada, O., Hanson, M. A., Cheng, A., Nogueras, C., Lasalde-Dominicci, J. A., and Stevens, R. C. (2008) Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments, J Membr Biol 223, 13-26. PMID: 18581036.
Wojna, V., Robles, L., Skolasky, R. L., Mayo, R., Selnes, O., de la Torre, T., Maldonado, E., Nath, A., Melendez, L. M., and Lasalde-Dominicci, J. (2007) Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women, J Neurovirol 13, 561-568. PMID: 18097887.
Otero-Cruz, J. D., Baez-Pagan, C. A., Caraballo-Gonzalez, I. M., and Lasalde-Dominicci, J. A. (2007) Tryptophan-scanning mutagenesis in the alphaM3 transmembrane domain of the muscle-type acetylcholine receptor. A spring model revealed, J Biol Chem 282, 9162-9171. PMID: 17242410.
Ochoa, E. L., and Lasalde-Dominicci, J. (2007) Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking, Cell Mol Neurobiol 27, 609-639. PMID: 17554626.
Zayas, R., Lasalde-Dominicci, J., and Gomez, C. M. (2006) Macroscopic properties of spontaneous mutations in slow-channel syndrome: correlation by domain and disease severity, Synapse 60, 441-449. PMID: 16881075.
Nieves-Cintron, M., Caballero-Rivera, D., Navedo, M. F., and Lasalde-Dominicci, J. A. (2006) Contribution of valine 7' of TMD2 to gating of neuronal alpha3 receptor subtypes, J Neurosci Res 84, 1778-1788. PMID: 17044037.
Navedo, M. F., Lasalde-Dominicci, J. A., Baez-Pagan, C. A., Diaz-Perez, L., Rojas, L. V., Maselli, R. A., Staub, J., Schott, K., Zayas, R., and Gomez, C. M. (2006) Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation, Mol Cell Neurosci 32, 82-90. PMID: 16624571.
Guzman, G. R., Ortiz-Acevedo, A., Ricardo, A., Rojas, L. V., and Lasalde-Dominicci, J. A. (2006) The polarity of lipid-exposed residues contributes to the functional differences between Torpedo and muscle-type nicotinic receptors, J Membr Biol 214, 131-138. PMID: 17530159.
Santiago, J., Guzman, G. R., Torruellas, K., Rojas, L. V., and Lasalde-Dominicci, J. A. (2004) Tryptophan scanning mutagenesis in the TM3 domain of the Torpedo californica acetylcholine receptor beta subunit reveals an alpha-helical structure, Biochemistry 43, 10064-10070. PMID: 15287734.
Ortiz-Acevedo, A., Melendez, M., Asseo, A. M., Biaggi, N., Rojas, L. V., and Lasalde-Dominicci, J. A. (2004) Tryptophan scanning mutagenesis of the gammaM4 transmembrane domain of the acetylcholine receptor from Torpedo californica, J Biol Chem 279, 42250-42257. PMID: 15247226.
Navedo, M., Nieves, M., Rojas, L., and Lasalde-Dominicci, J. A. (2004) Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha-TM3 domain in channel gating: differences between Torpedo and muscle-type AChR, Biochemistry 43, 78-84. PMID: 14705933.
Lopez-Hernandez, G. Y., Sanchez-Padilla, J., Ortiz-Acevedo, A., Lizardi-Ortiz, J., Salas-Vincenty, J., Rojas, L. V., and Lasalde-Dominicci, J. A. (2004) Nicotine-induced up-regulation and desensitization of alpha4beta2 neuronal nicotinic receptors depend on subunit ratio, J Biol Chem 279, 38007-38015. PMID: 15247303.
Rojas, L. V., Bonilla, L., Baez, S., and Lasalde-Dominicci, J. A. (2003) Thyroid hormones regulate the frequency of miniature end-plate currents in pre- and prometamorphic stages of the tadpole tail, J Neurosci Res 71, 670-678. PMID: 12584725.
Guzman, G. R., Santiago, J., Ricardo, A., Marti-Arbona, R., Rojas, L. V., and Lasalde-Dominicci, J. A. (2003) Tryptophan scanning mutagenesis in the alphaM3 transmembrane domain of the Torpedo californica acetylcholine receptor: functional and structural implications, Biochemistry 42, 12243-12250. PMID: 14567686.
Gomez, C. M., Maselli, R. A., Vohra, B. P., Navedo, M., Stiles, J. R., Charnet, P., Schott, K., Rojas, L., Keesey, J., Verity, A., Wollmann, R. W., and Lasalde-Dominicci, J. (2002) Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms, Ann Neurol 51, 102-112. PMID: 11782989.
Guzmán, G. M., Ortiz-Acevedo, A., Santiago, J., Rojas, L.V. and Lasalde-Dominicci, J. A., (Book Chapter) Regulation of Acetylcholine Receptor function by Cholesterol. In: Recent Research Developments in Membrane Biology: ISBN: 81-7736-181-3, p127-146, (2002).
Santiago, J., Guzman, G. R., Rojas, L. V., Marti, R., Asmar-Rovira, G. A., Santana, L. F., McNamee, M., and Lasalde-Dominicci, J. A. (2001) Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytes, J Biol Chem 276, 46523-46532. PMID: 11567020.
Cruz-Martin, A., Mercado, J. L., Rojas, L. V., McNamee, M. G., and Lasalde-Dominicci, J. A. (2001) Tryptophan substitutions at lipid-exposed positions of the gamma M3 transmembrane domain increase the macroscopic ionic current response of the Torpedo californica nicotinic acetylcholine receptor, J Membr Biol 183, 61-70. PMID: 11547353.
Tamamizu, S., Guzman, G. R., Santiago, J., Rojas, L. V., McNamee, M. G., and Lasalde-Dominicci, J. A. (2000) Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor, Biochemistry 39, 4666-4673. PMID: 10769122.
Tamamizu, S., Lee, Y., Hung, B., McNamee, M. G., and Lasalde-Dominicci, J. A. (1999) Alteration in ion channel function of mouse nicotinic acetylcholine receptor by mutations in the M4 transmembrane domain, J Membr Biol 170, 157-164. PMID: 10430659.
Ortiz-Miranda, S. I., Lasalde, J. A., Pappone, P. A., and McNamee, M. G. (1997) Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing, J Membr Biol 158, 17-30. PMID: 9211718.
Gomez, C. M., Maselli, R., Gundeck, J. E., Chao, M., Day, J. W., Tamamizu, S., Lasalde, J. A., McNamee, M., and Wollmann, R. L. (1997) Slow-channel transgenic mice: a model of postsynaptic organellar degeneration at the neuromuscular junction, J Neurosci 17, 4170-4179. PMID: 9151734.
Butler, D. H., Lasalde, J. A., Butler, J. K., Tamamizu, S., Zimmerman, G., and McNamee, M. G. (1997) Mouse-Torpedo chimeric alpha-subunit used to probe channel-gating determinants on the nicotinic acetylcholine receptor primary sequence, Cell Mol Neurobiol 17, 13-33. PMID: 9118205.
Tamamizu, S., Butler, D. H., Lasalde, J. A., and McNamee, M. G. (1996) Effects of antibody binding on structural transitions of the nicotinic acetylcholine receptor, Biochemistry 35, 11773-11781. PMID: 8794758.
Lasalde, J. A., Tamamizu, S., Butler, D. H., Vibat, C. R., Hung, B., and McNamee, M. G. (1996) Tryptophan substitutions at the lipid-exposed transmembrane segment M4 of Torpedo californica acetylcholine receptor govern channel gating, Biochemistry 35, 14139-14148. PMID: 8916899.
Gomez, C. M., Maselli, R., Gammack, J., Lasalde, J., Tamamizu, S., Cornblath, D. R., Lehar, M., McNamee, M., and Kuncl, R. W. (1996) A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome, Ann Neurol 39, 712-723. PMID: 8651643.
Vibat, C. R., Lasalde, J. A., McNamee, M. G., and Ochoa, E. L. (1995) Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus laevis oocytes, Cell Mol Neurobiol 15, 411-425. PMID: 8565045.
Lasalde, J. A., Colom, A., Resto, E., and Zuazaga, C. (1995) Heterogeneous distribution of acetylcholine receptors in chick myocytes induced by cholesterol enrichment, Biochim Biophys Acta 1235, 361-368. PMID: 7756346.
Lee, Y. H., Li, L., Lasalde, J., Rojas, L., McNamee, M., Ortiz-Miranda, S. I., and Pappone, P. (1994) Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function, Biophys J 66, 646-653. PMID: 7516721.
  Escalona De Motta, G., Mercado, J. A., Tosteson, T. R., Gonzalez, I., and Lasalde, J. A. (1992) Modulation of acetylcholine receptor channel by a polar component isolated from toxic Ostreopsis lenticularis extracts, Bull Soc Pathol Exot 85, 489-493. PMID: 1285088.
  Lasalde, J.A. (Book Chapter) A correlation between patch clamp and fluorescence anisotropy experiments to study alterations on the acetylcholine channel induced by cholesterol enrichment in chick myocytes. In: Membrane proteins: structures, interactions and models, Kluwer Academic Publishers, A. Pullman et al. (eds.) 199-212, (1992).
  Rojas, L., Lasalde, J.A. and Zuazága, C. El receptor nicotínico para la acetilcolina, importancia de enlaces disulfuro en la actividad unitaria. En: Investigaciones recientes sobre mecanismos de transporte de iones en membranas biológicas, A. Bendimyl Proeblo, (ed.) Monte Avila, 33-40, (1992).
  Eterovic, V. A., Escalona de Motta, G., Hann, R. M., Lasalde, J. A., Prieto, J. A., and Ferchmin, P. A. (1989) Positive modulators of muscle acetylcholine receptor, J Recept Res 9, 107-125. PMID: 2787401.
  Eterovic, V.A., Hann, R.M., Ferchmin, P.A., Escalona de Motta, G., Del Castillo, J., Prieto, J.A. and Lasalde, J.A. Positive modulators of acetylcholine receptors: differences between skeletal muscle and electric organ. In: Molecular Biology of Neuroreceptors and Ion Channels, NATO-ASI Series, A. Maelicke, (ed.) Vol. H 32: 565-584, (1989).